Contenuto dell'articolo principale

Abstract

 

SCOPO: piuÌ€ del 40% delle procedure chirurgiche sono condotte su soggetti ultrasessantacinquenni; cioÌ€ ha portato alla ribalta il concetto di fragilitaÌ€. Scopo di questo lavoro è compendiare le cono- scenze disponibili in letteratura per meglio comprendere quali siano gli aspetti essenziali della fragi- litaÌ€, quale sia l'impatto che essa ha sugli outcomes chirurgici dell'anziano e quali interventi appli- care per prevenirla.

METODI: EÌ€ stata condotta una revisione narrativa della letteratura utilizzando le principali banche dati bibliografiche di stampo biomedico ed infermieristico.

RISULTATI: Dall'analisi della letteratura è emerso che la fragilitaÌ€ è una sindrome medica con molte- plici cause caratterizzata da ridotte funzionalitaÌ€ fisiologiche e diminuita resistenza allo stress, che causa diversi outcome avversi a seguito degli interventi chirurgici. Negli studi considerati la fragi- litaÌ€, comunque essa venga considerata, è emersa come un indicatore attendibile di aumentata morbilitaÌ€ e mortalitaÌ€, di degenza ospedaliera protratta nel tempo, di istituzionalizzazione post- dimissione e di aumento dei costi sanitari. Per la correzione della fragilitaÌ€, l'intervento di maggior significato clinico è costituito dall'esercizio fisico.

CONCLUSIONI: L'identificazione di un paziente fragile nel preoperatorio consente agli operatori sanitari di trasmettere adeguatamente le informazioni riguardanti i rischi perioperatori individuali: dovrebbe fornire l'occasione di discutere riguardo alle aspettative ed ai desideri del paziente per il quale si prevede un esito postoperatorio sfavorevole. Inoltre, per i soggetti ad alto rischio, è possi- bile prevedere anticipatamente un percorso clinico con un programma di dimissioni ben struttu- rato, per evitare prolungamenti della degenza, diminuendo cosiÌ€ le spese per i ricoveri ospedalieri. PAROLE CHIAVE: FragilitaÌ€, anziano, chirurgia, outcome chirurgici

Elderly and surgery: impact of frailty on surgical outcome. A literature review.

ABSTRACT

AIM: Currently more than 40% of surgical procedures are performed on subjects over65 years. this event has brought to the fore the concept of frailty. The aim of this work is to summarize the knowledge available in the literature in order to better understand what are the essential aspects of frailty, which impact it has on surgical outcomes of the elderly and what action we need to apply to prevent it.

METHODS: A narrative literature review was conducted using the principal bibliographic biome- dical and nursing databases.

RESULTS: Literature analysis revealed that frailty is a medical syndrome with multiple causes characterized by reduced physiological functions and decreased stress resistance, resulting in several adverse outcome following surgery. In the selected studies, frailty has emerged as a reliable indi- cator of increased morbidity and mortality, long-term hospital stay, post-discharge institutionali- zation, and increased healthcare costs. For frailty prevention and treatment, the most important clinical intervention is physical exercise.

CONCLUSION: Identifying a patient like frail in the preoperative period allows the health profes- sional to adequately transmit information about individual perioperative risks. It should provide an opportunity to discuss the expectations and wishes of the patient for whom an adverse posto- perative outcome is expected. In addition, for high risk subjects, a clinical pathway with a well- structured discharge program can be anticipated in order to avoid hospital prolongations, thus reducing hospitalization costs.

KEYWORDS: Frail Elderly, Surgery/Surgical procedure, Outcome assessment

Dettagli dell'articolo

Come citare
Ronchi, S., Accardi, R., & Lusignani, M. (2019). Anziano e chirurgia: impatto della fragilità sugli outcome chirurgici. Una revisione della letteratura. PROFESSIONI INFERMIERISTICHE, 72(2). Recuperato da https://www.profinf.net/pro3/index.php/IN/article/view/626

Riferimenti

  • Adams, P., Ghanem, T., Stachler, R., Hall, F., Velanovich, V., & Rubinfeld, I. (2013). Frailty as a predictor of morbidity and mortality in inpatient head and neck surgery. JAMA Otolaryngology-- Head & Neck Surgery, 139(8), 783–789. https://doi.org/10.1001/jamaoto.2013.3969
  • Ambler, G. K., Brooks, D. E., Al Zuhir, N., Ali, A., Gohel, M. S., Hayes, P. D., ... Coughlin, P. A. (2015). Effect of frailty on short- and mid-term outcomes in vascular surgical patients. British Journal of Surgery, 102(6), 638–645. https://doi.org/10.1002/bjs.9785
  • Amrock, L. G., & Deiner, S. (2014). The implication of frailty on preoperative risk assessment: Current Opinion in Anaesthesiology, 27(3), 330–335. https://doi.org/10.1097/ACO.0000000000000065
  • Amrock, L. G., Neuman, M. D., Lin, H.-M., & Deiner, S. (2014). Can Routine Preoperative Data Predict Adverse Outcomes in
  • the Elderly? Development and Validation of a Simple Risk Model Incorporating a Chart-Derived Frailty Score. Journal of the American College of Surgeons, 219(4), 684–694. https://doi.org/10.1016/j.jamcollsurg.2014.04.018
  • Anaya, D. A., Johanning, J., Spector, S. A., Katlic, M. R., Perrino, A. C., Feinleib, J., & Rosenthal, R. A. (2014). Summary of the Panel Session at the 38th Annual Surgical Symposium of the Association of VA Surgeons: What Is the Big Deal About Frailty? JAMA Surgery, 149(11), 1191. https://doi.org/10.1001/jamasurg.2014.2064
  • Bavazzano A. et al. (2013). Linee Guida Regione Toscana - La fragilitaÌ€ nell'anziano. Retrieved November 21, 2015, from http://www.regione.toscana.it/consiglio-sanitario- regionale/linee-guida
  • Brown, N. A., & Zenilman, M. E. (2010). The Impact of Frailty in the Elderly on the Outcome of Surgery in the Aged. Advances in Surgery, 44(1), 229–249. https://doi.org/10.1016/j.yasu.2010.05.014
  • Buigues, C., Juarros-Folgado, P., FernaÌndez-Garrido, J., Navarro- MartiÌnez, R., & Cauli, O. (2015). Frailty syndrome and pre- operative risk evaluation: A systematic review. Archives of Gerontology and Geriatrics, 61(3), 309–321. https://doi.org/10.1016/j.archger.2015.08.002
  • Courtney-Brooks, M., Tellawi, A. R., Scalici, J., Duska, L. R., Jazaeri, A. A., Modesitt, S. C., & Cantrell, L. A. (2012). Frailty: an outcome predictor for elderly gynecologic oncology patients. Gynecologic Oncology, 126(1), 20–24. https://doi.org/10.1016/j.ygyno.2012.04.019
  • Dale, W., Hemmerich, J., Kamm, A., Posner, M. C., Matthews, J. B., Rothman, R., ... Roggin, K. K. (2014). Geriatric assessment improves prediction of surgical outcomes in older adults undergoing pancreaticoduodenectomy: a prospective cohort study. Annals of Surgery, 259(5), 960–965. https://doi.org/10.1097/SLA.0000000000000226
  • Dasgupta, M., Rolfson, D. B., Stolee, P., Borrie, M. J., & Speechley, M. (2009). Frailty is associated with postoperative complications in older adults with medical problems. Archives
  • of Gerontology and Geriatrics, 48(1),
  • –83.
  • https://doi.org/10.1016/j.archger.2007.10.007
  • Dunne, M. J., Abah, U., & Scarci, M. (2014). Frailty assessment in thoracic surgery. Interactive CardioVascular and Thoracic Surgery, 18(5), 667–670.
  • https://doi.org/10.1093/icvts/ivt542
  • Hewitt, J., Moug, S. J., Middleton, M., Chakrabarti, M., Stechman,
  • M. J., & McCarthy, K. (2015). Prevalence of frailty and its association with mortality in general surgery. The American Journal of Surgery, 209(2), 254–259. https://doi.org/10.1016/j.amjsurg.2014.05.022
  • Hodari, A., Hammoud, Z. T., Borgi, J. F., Tsiouris, A., & Rubinfeld, I. S. (2013). Assessment of morbidity and mortality after esophagectomy using a modified frailty index. The Annals of Thoracic Surgery, 96(4), 1240–1245. https://doi.org/10.1016/j.athoracsur.2013.05.051
  • Hubbard, R. E., & Story, D. A. (2014). Patient frailty: the elephant in the operating room. Anaesthesia, 69, 26–34. https://doi.org/10.1111/anae.12490
  • Johnson, M. S., Bailey, T. L., Schmid, K. K., Lydiatt, W. M., & Johanning, J. M. (2014). A frailty index identifies patients at high risk of mortality after tracheostomy. Otolaryngology-- Head and Neck Surgery: Official Journal of American Academy of Otolaryngology-Head and Neck Surgery, 150(4), 568–573. https://doi.org/10.1177/0194599813519749
  • Joseph, B., Pandit, V., Sadoun, M., Zangbar, B., Fain, M. J., Friese, R. S., & Rhee, P. (2014). Frailty in surgery: Journal of Trauma and Acute Care Surgery, 76(4), 1151–1156. https://doi.org/10.1097/TA.0000000000000103
  • Karam, J., Tsiouris, A., Shepard, A., Velanovich, V., & Rubinfeld, I. (2013). Simplified Frailty Index to Predict Adverse Outcomes and Mortality in Vascular Surgery Patients. Annals of Vascular Surgery, 27(7), 904–908. https://doi.org/10.1016/j.avsg.2012.09.015
  • Keller, D. S., Bankwitz, B., Nobel, T., & Delaney, C. P. (2014). Using Frailty to Predict Who Will Fail Early Discharge After Laparoscopic Colorectal Surgery With an Established Recovery Pathway: Diseases of the Colon & Rectum, 57(3), 337–342. https://doi.org/10.1097/01.dcr.0000442661.76345.f5
  • Kenig, J., Zychiewicz, B., Olszewska, U., Barczynski, M., & Nowak, W. (2015). Six screening instruments for frailty in older patients qualified for emergency abdominal surgery. Archives of Gerontology and Geriatrics, 61(3), 437–442. https://doi.org/10.1016/j.archger.2015.06.018
  • Kenig, J., Zychiewicz, B., Olszewska, U., & Richter, P. (2015). Screening for frailty among older patients with cancer that qualify for abdominal surgery. Journal of Geriatric Oncology, 6(1), 52–59. https://doi.org/10.1016/j.jgo.2014.09.179
  • Kim, S., Han, H.-S., Jung, H., Kim, K., Hwang, D. W., Kang, S.- B., & Kim, C.-H. (2014). Multidimensional Frailty Score for the Prediction of Postoperative Mortality Risk. JAMA Surgery, 149(7), 633. https://doi.org/10.1001/jamasurg.2014.241
  • Kristjansson, S. R., Nesbakken, A., Jordhí¸y, M. S., Skovlund, E., Audisio, R. A., Johannessen, H.-O., ... Wyller, T. B. (2010). Comprehensive geriatric assessment can predict complications in elderly patients after elective surgery for colorectal cancer: A prospective observational cohort study. Critical Reviews in Oncology/Hematology, 76(3), 208–217. https://doi.org/10.1016/j.critrevonc.2009.11.002
  • Lasithiotakis, K., Petrakis, J., Venianaki, M., Georgiades, G., Koutsomanolis, D., Andreou, A., ... Chalkiadakis, G. (2013). Frailty predicts outcome of elective laparoscopic cholecystectomy in geriatric patients. Surgical Endoscopy, 27(4), 1144–1150. https://doi.org/10.1007/s00464-012- 2565-0
  • Leung, J. M., Tsai, T. L., & Sands, L. P. (2011). Brief report: preoperative frailty in older surgical patients is associated with early postoperative delirium. Anesthesia and Analgesia, 112(5), 1199–1201. https://doi.org/10.1213/ANE.0b013e31820c7c06
  • Makary, M. A., Segev, D. L., Pronovost, P. J., Syin, D., Bandeen- Roche, K., Patel, P., ... Fried, L. P. (2010). Frailty as a predictor of surgical outcomes in older patients. Journal of the American College of Surgeons, 210(6), 901–908. https://doi.org/10.1016/j.jamcollsurg.2010.01.028
  • McAdams-DeMarco, M. A., Law, A., King, E., Orandi, B., Salter, M., Gupta, N., ... Segev, D. L. (2015). Frailty and mortality in kidney transplant recipients. American Journal of Transplantation: Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons, 15(1), 149–154. https://doi.org/10.1111/ajt.12992
  • McAdams-DeMarco, M. A., Law, A., Salter, M. L., Chow, E., Grams, M., Walston, J., & Segev, D. L. (2013). Frailty and early hospital readmission after kidney transplantation. American Journal of Transplantation: Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons, 13(8), 2091–2095. https://doi.org/10.1111/ajt.12300
  • Obeid, N. M., Azuh, O., Reddy, S., Webb, S., Reickert, C., Velanovich, V., ... Rubinfeld, I. (2012). Predictors of critical care-related complications in colectomy patients using the National Surgical Quality Improvement Program: exploring frailty and aggressive laparoscopic approaches. The Journal of Trauma and Acute Care Surgery, 72(4), 878–883.
  • https://doi.org/10.1097/TA.0b013e31824d0f70 Ommundsen, N., Wyller, T. B., Nesbakken, A., Jordhí¸y, M. S., Bakka, A., Skovlund, E., & Rostoft, S. (2014). Frailty is an independent predictor of survival in older patients with colorectal cancer. The Oncologist, 19(12), 1268–1275.
  • https://doi.org/10.1634/theoncologist.2014-0237
  • Partridge, J. S. L., Harari, D., & Dhesi, J. K. (2012). Frailty in the older surgical patient: a review. Age and Ageing, 41(2), 142–
  • https://doi.org/10.1093/ageing/afr182
  • Payne, S., Davies, K., & Powell, N. (2014). 22 * FRAILTY
  • SCORES TO TARGET' AT RISK' ACUTE SURGICAL ADMISSIONS. Age and Ageing, 43(suppl 2), ii6–ii6. https://doi.org/10.1093/ageing/afu124.22
  • Pol, R. A., van Leeuwen, B. L., Visser, L., Izaks, G. J., van den Dungen, J. J. A. M., Tielliu, I. F. J., & Zeebregts, C. J. (2011). Standardised Frailty Indicator as Predictor for Postoperative Delirium after Vascular Surgery: A Prospective Cohort Study. European Journal of Vascular and Endovascular Surgery, 42(6), 824–830. https://doi.org/10.1016/j.ejvs.2011.07.006
  • Reisinger, K. W., van Vugt, J. L. A., Tegels, J. J. W., Snijders, C., HulseweÌ, K. W. E., Hoofwijk, A. G. M., ... Poeze, M. (2015). Functional compromise reflected by sarcopenia, frailty, and nutritional depletion predicts adverse postoperative outcome after colorectal cancer surgery. Annals of Surgery, 261(2), 345–352. https://doi.org/10.1097/SLA.0000000000000628
  • Revenig et al. (2013). Hopkins Frailty Score is best predictor of postoperative complications. Operating Theatre Journal, 227, 4.
  • Revenig, L. M., Canter, D. J., Kim, S., Liu, Y., Sweeney, J. F., Sarmiento, J. M., ... Ogan, K. (2015). Report of a Simplified Frailty Score Predictive of Short-Term Postoperative Morbidity and Mortality. Journal of the American College of Surgeons, 220(5), 904–911.e1. https://doi.org/10.1016/j.jamcollsurg.2015.01.053
  • Robinson, T. N., Eiseman, B., Wallace, J. I., Church, S. D., McFann, K. K., Pfister, S. M., ... Moss, M. (2009). Redefining geriatric preoperative assessment using frailty, disability and co-morbidity. Annals of Surgery, 250(3), 449– 455. https://doi.org/10.1097/SLA.0b013e3181b45598
  • Robinson, T. N., Wallace, J. I., Wu, D. S., Wiktor, A., Pointer, L. F., Pfister, S. M., ... Moss, M. (2011). Accumulated frailty characteristics predict postoperative discharge institutionalization in the geriatric patient. Journal of the American College of Surgeons, 213(1), 37–42; discussion 42– 44. https://doi.org/10.1016/j.jamcollsurg.2011.01.056
  • Robinson, T. N., Wu, D. S., Pointer, L., Dunn, C. L., Cleveland, J. C., & Moss, M. (2013). Simple frailty score predicts postoperative complications across surgical specialties. American Journal of Surgery, 206(4), 544–550. https://doi.org/10.1016/j.amjsurg.2013.03.012
  • Robinson, T. N., Wu, D. S., Stiegmann, G. V., & Moss, M. (2011). Frailty predicts increased hospital and six-month healthcare cost following colorectal surgery in older adults. American Journal of Surgery, 202(5), 511–514. https://doi.org/10.1016/j.amjsurg.2011.06.017
  • Rí¸nning, B., Wyller, T. B., Seljeflot, I., Jordhí¸y, M. S., Skovlund, E., Nesbakken, A., & Kristjansson, S. R. (2010). Frailty measures, inflammatory biomarkers and post-operative complications in older surgical patients. Age and Ageing, 39(6), 758–761. https://doi.org/10.1093/ageing/afq123
  • Tan, K.-Y., Kawamura, Y. J., Tokomitsu, A., & Tang, T. (2012). Assessment for frailty is useful for predicting morbidity in elderly patients undergoing colorectal cancer resection whose comorbidities are already optimized. The American Journal of Surgery, 204(2), 139–143. https://doi.org/10.1016/ j.amjsurg.2011.08.012